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6-MP and AZA for Crohns Human Para Foundation

Azathioprine (brand name Imuran) is a prodrug of 6-MP which is converted to 6-MP by the liver. ... 6-MP was first discovered in 1951 by the team of Gertrude B. Elion and George H. Hitchings at the pharmaceutical company Burroughs Wellcome, which later merged to become GlaxoSmithKline. Azathioprine was discovered in 1957 by the same team.…

Azathioprine - Wikipedia

Azathioprine (AZA), sold under the brand name Imuran among others, is an immunosuppressive medication. It is used in rheumatoid arthritis, granulomatosis with polyangiitis, Crohn's disease, ulcerative colitis, systemic lupus erythematosus, and in kidney transplants to prevent rejection. It is taken by mouth or injected into a vein.Metabolism: Activated non-enzymatically, deactivated ……